The Ohio River Scenic Route is located in the south and eastern, near and comprising the entire southern border and part of the eastern border of Ohio.
From Cleveland, Ohio, (beginning the Byway at East Liverpool):
Take Interstate 77 south to Akron and its junction with Interstate 76 east.
Travel I-76 east to its junction with State Route 11 outside of Youngstown.
State Route 11 will turn into US 30 near East Liverpool, and then it will join with State Route 7 and the Ohio River Scenic Byway.
From Columbus, Ohio (beginning the Byway at Marietta, Ohio):
Take Interstate 70 east of the National Road/US 40 to Zanesville and the junction of State Route 60 south, or continue east on Interstate 70 to Cambridge and Interstate 77 south. Both State Route 60 south and Interstate 77 south will join with State Route 7 and the Ohio River Scenic Byway in Marietta, Ohio.
From Columbus, Ohio (beginning the Byway at Portsmouth, Ohio):
Take US 23 south towards Chillicothe, Ohio.
Continue on US 23 into Portsmouth and its junction with US 52 and the Ohio River Scenic Bwyay.
From Pittsburgh, Pennsylvania (beginning the Byway at East Liverpool):
Take US 22/30 west from Pittsburgh.Turn north onto US 60 and continue to Vanport, Pennsylvania.
Take US 68 west from Vanport to East Liverpool, Ohio, where it becomes State Route 39 and the beginning of the Ohio River Scenic Byway.
From Louisville, Kentucky (beginning the Byway at Cincinnati, Ohio):
Take Interstate 71 north into Cincinnati where it joins with Interstate 75 north.
Continue on Interstate 71 north to its junction with US 52 and the beginning of the Ohio River Scenic Byway.
From Lexington, Kentucky (beginning the Byway at Cincinnati, Ohio):
Take Interstate 75 north into Cincinnati, where it joins with Interstate 71 north.
Continue on Interstate 71 north to its junction with US 52 and the beginning of Ohio River Scenic Byway.
From Indianapolis, Indiana (beginning the Byway at Cleves, Ohio):
Take Interstate 74 east to Interstate 275.
Head south on Interstate 275 towards Cleves, Ohio.
In Cleves, US 50 and the Ohio River Scenic Byway begin.
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